• May 23, 2024

Double Marker Test Report: What’s Normal? What’s Not?

 Double Marker Test Report: What’s Normal? What’s Not?

. S.When it comes to prenatal screening, a Double Marker Test is one of the most common tests available. It can detect the presence of specific abnormalities in your baby’s development, such as Down Syndrome and Trisomy 18. But what does a Double Marker Test report mean? How do you interpret the results? In this overview of the Double Marker test, we explain what is considered “normal” and “abnormal” regarding the results, in addition to discussing other factors that may affect the accuracy of these tests.

What is the Double Marker Test?

The Double Marker Test is a kind of blood test that helps to measure the two different markers in the blood. The first marker is called the alpha-fetoprotein (AFP) level, and the second marker is called the beta human chorionic gonadotropin (beta-hCG) level. While the AFP level is a protein that is produced by the liver of a developing fetus, the beta-hCG level is a hormone produced by the placenta of a pregnant woman. 

What is the purpose of the test?

The purpose of the double marker test is to screen for chromosomal abnormalities in developing babies. It is typically done between the 10th and 14th weeks of pregnancy. The test involves taking a blood sample from the mother and testing it for two specific markers:

1) Pregnancy-associated plasma protein-A (PAPP-A): This protein is produced by the placenta and is elevated in pregnant women with specific chromosomal abnormalities, such as Down syndrome.

2) Human chorionic gonadotropin (hCG): This hormone is produced by the placenta and is elevated in the blood of pregnant women with specific chromosomal abnormalities, such as Edward syndrome.

How is the test performed?

The Double Marker Test is one blood test that is used to screen for certain birth defects. 

The levels of the markers that are measured can be affected by certain birth defects, such as Down syndrome, Edward syndrome, and Patau syndrome.

What do the results mean?

The Double Marker Test report can be challenging to interpret, as there is no definitive “normal” or “abnormal” result. However, the test can provide some vital information about the risk of certain birth defects.

A positive result on the test may indicate an increased risk for certain conditions, such as Down syndrome, trisomy 18, or any kind of neural tube defects. However, it is essential to note that not all women with positive results will go on to have a baby with these conditions. Conversely, a negative impact does not guarantee that a woman will not have a baby with one of these conditions.

Ultimately, the decision about whether or not to proceed with further testing or opt for a medical termination of pregnancy is a personal one that should be made after consulting with a genetic counselor or a healthcare provider.


A double marker test is an essential tool in assessing the risk of a baby having chromosomal abnormalities. It is vital to be aware that the results of this test may not always be accurate in diagnosing or excluding these types of conditions, and further testing may be required. However, understanding what’s normal versus abnormal on a Double Marker Test report can help you stay informed about your pregnancy and make decisions about your healthcare that are best for you and your baby.


Shabbir Ahmad


Shabbir Ahmed is a professional blogger, writer, SEO expert & founder of Dive in SEO. With over 5 years of experience, he handles clients globally & also educates others with different digital marketing tactics.